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    VAKCINA

    rumbeando

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    Post by rumbeando 07.05.21 9:29

    Nažalost, uopšte nije neočekivano od Nemaca: od 3 iRNK vakcine koje su već (Biontech-Pfizer i Moderna) ili će uskoro biti u igri (Curevac), njihove su dve. Pritom je ta treća mnogo termički stabilnija, treća faza se privodi kraju i EMA je započela onaj sukcesivni pregled dokumentacije.





    Kjurvak pritom koristi 8x manje RNK materijala od Moderne, odnosno 2,5x manje od Bionteka, što bi trebalo da znači da će obim proizvodnje moći brže da se poveća.

    The current mRNA vaccine doses range from 30 micrograms (Pfizer/BioNTech) to 100 micrograms (Moderna). In phase 1 clinical trials, lower doses of the Pfizer/BioNTech vaccine were also active.
     
    Could we go lower than this? CureVac has developed a COVID-19 mRNA vaccine with a dose of 12 micrograms through a combination of innovations in mRNA sequence and lipid formulations. However, the details of this remain proprietary.
    https://www1.racgp.org.au/newsgp/clinical/four-things-about-mrna-covid-vaccines-researchers
    rumbeando

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    Post by rumbeando 07.05.21 12:55

    lalinea

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    Post by lalinea 07.05.21 14:16

    Mislila sam da ce biti "cika Vucicu, jel moze meni jedan fajzer", ali iznenadise Svajcarci - bukirali smo termin za vakcinu 9 jun (pa druga doza za 4 nedelje). Ovde su samo Fajzer i Moderna u opticaju.

    A evo kako izgleda ona mitska svajcarska organizovanost i efikasnost:
    - od jutros je svima (preko 16god) u kantonu Cirih otvorena mogucnost da bukiraju termin za vakcinu.
    - portal (koji je naravno jutros pao) ti dozvoljava da bukiras termin samo ako u isto vreme bukiras i vakcinu i revakcinu, ne moze nikako samo vakcina.
    - oba termina moraju da se bukiraju na istom mestu.
    - mesta vakcinacije su jedno ~10 vakcina centara i nekoliko stotina apoteka.
    - uz nekoliko izuzetaka, koji su se popunili u roku od odmah, apoteke uopste nisu postavile termine mesec ili dva unapred, sto je potrebno za revakcinu.
    Drugim recima, od nekoliko stotina vakcina punktova u Cirihu, trenutno moze uspesno (nakon sat vremena refresovanja) da se bukira smao na desetak mesta.


    _____
    you cannot simply trust a language model when it tells you how it feels
    rumbeando

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    Post by rumbeando 07.05.21 14:19

    Allie Nawrat: How does CureVac’s CVnCoV differ from the other mRNA vaccines in development, such as Moderna’s and Pfizer/BioNTech’s?

    [CureVac chief technology officer] Mariola Fotin-Mleczek: We spent many years researching naturally occurring mRNA molecules and now have a library of elements that can be used to build the specific mRNA nucleotide sequence needed for each specific protein. We are now leveraging this extensive expertise into the safe and rapid development and manufacturing of our Covid-19 candidate.

    CureVac’s approach is to use non-modified mRNA. We believe this enables improved interactions with intracellular translation machinery, leading to high protein production and a moderate activation of innate immunity. We [also] believe this approach closely mimics the natural immune response to Covid-19; our studies confirm that we see similar ratios of binding and neutralising antibodies in vaccinated individuals and convalescent patients.

    The dose of CVnCoV proposed for Phase IIb/III [trial] is the lowest dose of any of the mRNA vaccine candidates in advanced clinical trials. Our optimisation process enables high expression levels of the encoded protein, which ultimately means we can use a lower dose.

    AN: How has CureVac developed an mRNA vaccine that does not require ultra-cold refrigeration?

    MF-M: The most obvious difference between our vaccine and the other mRNA-based vaccines is the use of natural, non-modified mRNA, which impacts secondary structure and packing of mRNA, which can make mRNA less affected to hydrolysis. This is one of the possible explanations. But, also, the matrix can differ between different mRNA approaches.


    https://www.pharmaceutical-technology.com/features/mrna-vaccines-covid19-pandemic-curevac/
    rumbeando

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    Post by rumbeando 07.05.21 16:44


    Anonymous
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    Post by Guest 07.05.21 17:42

    GENEVA (AP) — The World Health Organization on Friday gave its authorization for emergency use of a COVID-19 vaccine manufactured by China’s Sinopharm, potentially paving the way for millions of the doses to reach needy countries through a U.N.-backed program rolling out coronavirus vaccines.

    The decision by a WHO technical advisory group opens the possibility that the Sinopharm vaccine could be included into the U.N.-backed COVAX program in coming weeks or months, and distributed through UNICEF and WHO’s regional office in the Americas.

    Sinopharm has released very little data publicly, aside from efficacy numbers for its two vaccine shots – one developed by its Beijing Institute of Biological Products and the other by the Wuhan Institute of Biological Products.

    The Beijing shot is one that was considered by WHO for the emergency use listing.

    “This afternoon, WHO gave emergency use listing to sign off on Beijing’s COVID-19 vaccine, making it the sixth vaccine to receive WHO validation for safety, efficacy and quality,” WHO Director-General Tedros Adhahom Ghebreysus said. “This expands the list of vaccines that COVAX can buy and gives countries confidence to expedite their own regulatory approval and to import and administer a vaccine.”

    A separate group advising the U.N. agency on vaccines said it was “very confident” the Sinopharm vaccine protects people ages 18-59. The group said it had a “low level of confidence” of the vaccine’s efficacy in people 60 and over. Its members said they had “very low confidence” in the available data about serious side effects in that age group.
    Јанош Винету

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    Post by Јанош Винету 07.05.21 18:15

    VAKCINA - Page 11 938375017 VAKCINA - Page 11 2880169504
    VAKCINA - Page 11 4286502047


    _____
    Burundi is an exception among other nations because it is a country which gave God first place, a God who guards and protects from all misfortune.
    Burundi... opskurno udruženje 20ak levičarskih intelektualaca, kojima je fetiš odbrana poniženih i uvredjenih.
    rumbeando

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    Post by rumbeando 07.05.21 19:36

    rumbeando

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    Post by rumbeando 07.05.21 20:02

    Solus_Rex

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    Post by Solus_Rex 07.05.21 20:42



    _____
    "Sisaj kurac, Boomere. Spletkario si i nameštao ban pa se sad izvlačiš. Radiša je format a ti si mali iskompleksirani miš. Katastrofa za Burundi čoveče.
    A i deluje da te napustio drugar u odsudnom trenutku pa te spašavaju ova tovarka što vrv ni ne dismr na ribu, to joj se gadi, i ovaj južnjak koji o niškim kafanama čita na forumu. Prejaka šarža."  - Monsier K.
    kondo

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    Post by kondo 07.05.21 22:14

    a mor neverue   VAKCINA - Page 11 3579118792


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    #FreeFacu

    Дакле, волео бих да се ЈСД Партизан угаси, али не и да сви (или било који) гробар умре.
    Sotir

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    Post by Sotir 07.05.21 22:18

    Marius Lăcătuș wrote:a mor neverue   VAKCINA - Page 11 3579118792
    Хоће ли објавити кад може да се рокне Фајзер преко Синофарма, да не морамо више да слушамо Морово кукање?
    Nektivni Ugnelj

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    Post by Nektivni Ugnelj 07.05.21 22:21

    Marius Lăcătuș wrote:a mor neverue   VAKCINA - Page 11 3579118792

    Zasto ne bih verovao, ovo se znalo da ce biti ima bar nedelju dana.
    Nektivni Ugnelj

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    Post by Nektivni Ugnelj 07.05.21 22:21

    Sotir wrote:
    Marius Lăcătuș wrote:a mor neverue   VAKCINA - Page 11 3579118792
    Хоће ли објавити кад може да се рокне Фајзер преко Синофарма, да не морамо више да слушамо Морово кукање?

    Ne znam dal cu Fajzer.
    kondo

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    Post by kondo 07.05.21 22:27

    nema za rajka kapa


    _____
    #FreeFacu

    Дакле, волео бих да се ЈСД Партизан угаси, али не и да сви (или било који) гробар умре.
    rumbeando

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    Post by rumbeando 08.05.21 12:08

    Odlazeći šef britanske radne grupe za vakcinaciju dosta optimističan, ove jeseni i zime neće biti značajnog prisustva virusa u Britaniji, 3. doza tek u januaru-februaru:

    COVID-19: 'Britain will be free of the coronavirus by August', says outgoing vaccine taskforce chief

    The UK will have a population protected from COVID by midsummer, the departing chief of the UK's vaccine taskforce says.

    The coronavirus will no longer be circulating in Britain by midsummer, according to the government's departing vaccine taskforce chief, Clive Dix.

    Mr Dix, who was appointed as interim leader of the taskforce in December and stepped down last week, said it was his belief there would be no circulating virus "sometime in August".

    He also told the Daily Telegraph that he expects everyone in the UK to have been vaccinated at least once by the end of July, by which time "we'll have probably protected the population from all the variants that are known".

    "We'll be safe over the coming winter," he added.

    More than 35 million people have received the first dose of a COVID-19 vaccine as the UK reported another 15 deaths related to the virus.

    On Friday, there were 2,490 new cases reported in the latest 24-hour period, according to government figures.

    Earlier this week, vaccines minister Nadhim Zahawi said scientists are looking at a range of options for an autumn vaccine booster programme to protect against a third wave of the virus.

    But Mr Dix said he believed this could be pushed back to early 2022.

    He told the paper: "We may decide that we need to boost the immune response, and we've got the vaccine to do that. Whether we'll need to or not, I would think probably not, but we might still do it in case.

    "I really don't think it should be autumn. We should be thinking about boosting in maybe January or February, because the immune response will be strong."
    https://news.sky.com/story/covid-19-britain-will-be-free-of-the-coronavirus-by-august-says-outgoing-vaccine-taskforce-chief-12300112?dcmp=snt-sf-twitter
    kondo

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    Post by kondo 08.05.21 12:17

    a sad ozbiljno, ko se nije zarazio (a nije baš živeo u skafanderu) niti imao druge probleme sa sinofarmom, mislim da nema razloga da menja vakcinu. prosto, treći shot na jesen i zdravo ćao. na proleće sledeće godine ćemo videti šta smo gde smo.


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    #FreeFacu

    Дакле, волео бих да се ЈСД Партизан угаси, али не и да сви (или било који) гробар умре.
    rumbeando

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    Post by rumbeando 08.05.21 14:05

    7.5.
    Укупно вакцинација: 3.757.088, од тога ревакцинација: 1.640.502

    5.5.
    Укупно вакцинација: 3.692.416, од тога ревакцинација: 1.620.781

    2.5.
    Укупно вакцинација: 3.526.876, од тога ревакцинација: 1.498.386
    https://vakcinacija.gov.rs/

    Trenutno vakcinisanih samo 1. dozom: 476.084
    Trenutno vakcinisanih s obe doze: 1.640.502
    Ukupan broj osoba vakcinisanih barem jednom dozom: 2.071.635

    Datih doza za ova dva dana: 64.672, tj. oko 32.000 dnevno
    Revakcinisanih: 19.721, tj. oko 10.000 dnevno
    Vakcinisanih prvom dozom: 44.951, tj. oko 22.000 dnevno

    Datih doza za prethodna tri dana: 165.540, tj. oko 55.000 dnevno
    Revakcinisanih: 122.395, tj. oko 41.000 dnevno
    Vakcinisanih prvom dozom: 43.145, tj. oko 14.000 dnevno

    Ukupan broj dnevno datih doza se smanjio, očigledno je prošla ona nadoknada revakcinacije posle praznika, ali je broj dnevno datih prvih doza osetno porastao, ali nije eksplodirao nakon Vučićeve najave.
    Janko Suvar

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    Post by Janko Suvar 08.05.21 14:23

    Његово Преосвештенство Епископ будимљанско-никшићки и администратор Митрополије црногорско-приморске г. Јоаникије данас 7. маја 2021. године, у катедралном манастиру Ђурђеви Ступови примио је прву дозу вакцине Pfizer-BioNTech COVID-19.


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    ????
    Anonymous
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    Post by Guest 08.05.21 14:40

    pičketina, a ne ko đedo
    rumbeando

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    Post by rumbeando 08.05.21 15:33

    14 vakcina dosad je odobreno za upotrebu u makar jednoj zemlji. Evo spiska vakcina sortiranog po broju država u kojima su odobrene.

    Broj zemalja u kojima je odobrena, proizvođač, naziv vakcine, tip, država u kojoj je razvijena

    98 Oxford/AstraZeneca, AZD1222 - Vaxzevria, vektorska /UK/
    84 Pfizer/BioNTech, BNT162b2 - Tozinameran - Comirnaty, iRNK /DE/
    65 Gamaleja, Sputnik V - Gam-COVID-Vac, vektorska /RU/
    45 Moderna, mRNA-1273, iRNK /US/
    41 Janssen tj. Johnson & Johnson, Ad26.COV2.S - Ad26COVS1 - JNJ-78436735, vektorska /NL/
    40 Sinopharm (Beijing), BBIBP-CorV, inaktivisani virus /CN/
    40 Serum Institute of India, Covishield (ista kao oksfordska), vektorska /UK/
    24 Sinovac, CoronaVac, inaktivisani virus /CN/
    9 Bharat Biotech, Covaxin - BBV152, inaktivisani virus /IN/
    5 CanSino, Ad5-nCoV, Convidecia, vektorska /CN/
    2 Anhui Zhifei Longcom, RBD-Dimer - ZF2001, proteinska /CN/
    2 Vektor, EpiVacCorona, proteinska /RU/
    2 Sinopharm (Wuhan), Inactivated (Vero Cells), inaktivisani virus /CN/
    1 Čumakov, KoviVac, inaktivisani virus /RU/

    https://covid19.trackvaccines.org/vaccines/
    Anonymous
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    Post by Guest 08.05.21 15:44

    kuba?
    rumbeando

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    Post by rumbeando 08.05.21 15:57

    Nisu odobrene.

    Two Cuban COVID-19 vaccines are in solid progress to be available in summer, Dr. Rolando Perez Rodriguez, director of Science and Innovation at the Cuban Biotechnology and Pharmaceutical Industries Group (BioCubaFarma), told Anadolu Agency in an exclusive interview.
    ...
    Two vaccine candidates – Soberana 02 and Abdala – are now in Phase III clinical trials, Rodriguez said, with ''efficacy data expected by June."

    "However, positive safety and immunogenicity data from these vaccine candidates have been obtained in previous clinical trials," he added.

    He said Cuba plans to complete vaccination of all its people, against all odds, before the end of this year and drew attention to "a shortage worldwide for available supplies of raw materials and primary packaging material for the pharmaceutical industry."
    https://www.aa.com.tr/en/americas/cubas-2-covid-19-vaccines-might-be-ready-in-summer/2228075

    With around 100,000 Cubans having received the jab so far, the island is behind the average Latin American vaccine rollout of 12% of people having received at least one dose. And with no vaccine yet fully approved for use by the island’s regulator, critics say the Communist party’s decision not to join Covax, the UN-backed mechanism to distribute Covid-19 doses fairly around the world, was arrogant and has left them needlessly exposed.
    https://www.theguardian.com/world/2021/may/04/cuba-covid-vaccines

    FINLAY-FR-2 tj. Soberana 2 je konjugovana vakcina, a CIGB-66 tj. Abdala je proteinska.
    rumbeando

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    Post by rumbeando 08.05.21 17:12





    Mr.Pink

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    Post by Mr.Pink 08.05.21 20:56

    Zato se vucicu zuri

    U americi skandal nestasica radne snage

    Ako nece lenji crnjo da radi jer besplatna lova

    Moze uskoci vucko sa jevtinom srbadijom da pokrije


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    radikalni patrijarhalni feminista

    smrk kod dijane hrk

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