Virus

Scientists in China believe new drug can stop coronavirus pandemic 'without vaccine'

BEIJING (AFP) - A Chinese laboratory has been developing a drug it believes has the power to bring the coronavirus pandemic to a halt.

The outbreak first emerged in China late last year before spreading across the world, prompting an international race to find treatments and vaccines.

A drug being tested by scientists at China's prestigious Peking University could not only shorten the recovery time for those infected, but even offer short-term immunity from the virus, researchers say.

Sunney Xie, director of the university's Beijing Advanced Innovation Centre for Genomics, told AFP that the drug has been successful at the animal testing stage.

"When we injected neutralising antibodies into infected mice, after five days the viral load was reduced by a factor of 2,500," said Xie. "That means this potential drug has (a) therapeutic effect."

The drug uses neutralising antibodies - produced by the human immune system to prevent the virus infecting cells - which Xie's team isolated from the blood of 60 recovered patients.

A study on the team's research, published Sunday (May 17) in the scientific journal Cell, suggests that using the antibodies provides a potential "cure" for the disease and shortens recovery time.

Xie said his team had been working "day and night" searching for the antibody.

"Our expertise is single-cell genomics rather than immunology or virology. When we realised that the single-cell genomic approach can effectively find the neutralising antibody we were thrilled."

He added that the drug should be ready for use later this year and in time for any potential winter outbreak of the virus, which has infected 4.8 million people around the world and killed more than 315,000.

"Planning for the clinical trial is underway," said Xie, adding it will be carried out in Australia and other countries since cases have dwindled in China, offering fewer human guinea pigs for testing.

"The hope is these neutralised antibodies can become a specialised drug that would stop the pandemic," he said.

China already has five potential coronavirus vaccines at the human trial stage, a health official said last week.

But the World Health Organisation has warned that developing a vaccine could take 12 to 18 months.

Scientists have also pointed to the potential benefits of plasma - a blood fluid - from recovered individuals who have developed antibodies to the virus enabling the body's defences to attack it.

More than 700 patients have received plasma therapy in China, a process which authorities said showed "very good therapeutic effects".

"However, it (plasma) is limited in supply," Xie said, noting that the 14 neutralising antibodies used in their drug could be put into mass production quickly.

PREVENTION AND CURE
Using antibodies in drug treatments is not a new approach, and it has been successful in treating several other viruses such as HIV, Ebola and Middle East Respiratory Syndrome (MERS).

Xie said his researchers had "an early start" since the outbreak started in China before spreading to other countries.

Ebola drug Remdesivir was considered a hopeful early treatment for Covid-19 - clinical trials in the US showed it shortened the recovery time in some patients by a third - but the difference in mortality rate was not significant.

The new drug could even offer short-term protection against the virus.

The study showed that if the neutralising antibody was injected before the mice were infected with the virus, the mice stayed free of infection and no virus was detected.

This may offer temporary protection for medical workers for a few weeks, which Xie said they are hoping to "extend to a few months".

More than 100 vaccines for Covid-19 are in the works globally, but as the process of vaccine development is more demanding, Xie is hoping that the new drug could be a faster and more efficient way to stop the global march of the coronavirus.

"We would be able to stop the pandemic with an effective drug, even without a vaccine," he said.

Mr.Pink wrote:Autopsies Prove that COVID-19 is a Disseminated Intravascular Coagulation (Pulmonary Thrombosis)
It is now clear that the whole world has been attacking the so-called Coronavirus Pandemic wrongly due to a serious pathophysiological diagnosis error.
According to valuable information from Italian pathologists, ventilators and intensive care units were never needed.
Autopsies performed by the Italian pathologists have shown that it is not pneumonia but it is Disseminated Intravascular Coagulation (Thrombosis) which ought to be fought with antibiotics, antivirals, anti-inflammatories and anticoagulants.
If this is true for all cases, that means the whole world is about to resolve this novel pandemic earlier than expected.
However, protocols are currently being changed in Italy who have been adversely affected by this pandemic.
The impressive case of a Mexican family in the United States who claimed they were cured with a home remedy was documented: three 500 mg aspirins dissolved in lemon juice boiled with honey, taken hot. The next day they woke up as if nothing had happened to them! Well, the scientific information that follows proves they are right!
This information was released by a medical researcher from Italy:
“Thanks to 50 autopsies performed on patients who died of COVID-19, Italian pathologists have discovered that IT IS NOT PNEUMONIA, strictly speaking because the virus does not only kill pneumocytes of this type but uses an inflammatory storm to create an endothelial vascular thrombosis.”
In disseminated intravascular coagulation, the lung is the most affected because it is the most inflamed, but there is also a heart attack, stroke and many other thromboembolic diseases.
In fact, the protocols left antiviral therapies useless and focused on anti-inflammatory and anti-clotting therapies. These therapies should be done immediately, even at home, in which the treatment of patients responds very well.
If the Chinese had denounced it, they would have invested in-home therapy, not intensive care! So, the way to fight it is with antibiotics, anti-inflammatories and anticoagulants.
An Italian pathologist reports that the hospital in Bergamo did a total of 50 autopsies and one in Milan, 20, that is, the Italian series is the highest in the world, the Chinese did only 3, which seems to fully confirm the information.
In a nutshell, the disease is determined by disseminated intravascular coagulation triggered by the virus; therefore, it is not pneumonia but pulmonary thrombosis, a major diagnostic error.
Some world leaders doubled the number of resuscitation places in the ICU, with unnecessary exorbitant costs.
According to the Italian pathologist, treatment in ICUs is useless if thromboembolism is not resolved first. “If we ventilate a lung where blood does not circulate, it is useless, in fact, nine (9) patients out of ten (10) will die because the problem is cardiovascular, not respiratory.”
“It is venous micro thrombosis, not pneumonia, that determines mortality.”
According to the literature, inflammation induces thrombosis through a complex but well-known pathophysiological mechanism.
Unfortunately, what the scientific literature said, especially Chinese until mid-March was that anti-inflammatory drugs should not be used.
Now, the therapy being used in Italy is with anti-inflammatories and antibiotics, as in influenza, and the number of hospitalized patients has been reduced.
He also discovered that many deaths, even in their 40s, had a history of fever for 10 to 15 days, which were not treated properly.
The inflammation does a great deal of tissue damage and creates ground for thrombus formation. However, the main problem is not the virus, but the immune hyper reaction that destroys the cell where the virus is installed.
In fact, patients with rheumatoid arthritis have never needed to be admitted to the ICU because they are on corticosteroid therapy, which is a great anti-inflammatory.
With this important discovery, it is possible to return to normal life and open closed deals due to the quarantine, though not immediately, but with time.
Kindly share so that the health authorities of each country can make their respective analysis of this information, prevent further deaths and redirect investments appropriately; the vaccine may come later.

rumbeando wrote:Budalaština.

https://factcheck.afp.com/who-warns-against-self-medicating-covid-19-aspirin-lemon-juice-and-honey-remedy

Ferenc Puskás wrote:naš krizni štab s glavnim epidemiologom Burundija

rumbeando wrote:0 slučajeva u Vranju danas po Excel fajlu dnevne geografske raspodele, iako je tamošnji epidemiolog izjavio da je uzeto 320 uzoraka.

https://covid19.data.gov.rs/infected
https://www.rts.rs/page/stories/sr/Коронавирус/story/3134/koronavirus-u-srbiji/3958686/epidemija-vranje-koronavirus-situacija.html

Biće sutra opet povećanje.

Mr.Pink wrote:neverovatno je da kada izguglam ovu narodnu medicinu, izleti mi jedno 50 odgovora i svi su u fazonu FALSE

Halászlé wrote:Ne vidim šta je sporno.

rumbeando wrote:

Halászlé wrote:Ne vidim šta je sporno.

I te kako je sporno to što iz ubedljivo najvećeg žarišta u državi (pri čemu je u ostatku zemlje situacija vrlo povoljna) nisu u stanju da makar približno kontinualno obrađuju uzorke već ih odande na analizu šalju jednom u dan-dva.

Postojeći koronavirus u Hubeiju više nije visoko zarazan

2020-05-19 10:17:03  |  CRI  

Sve manje slučajeva koronavirusa bez simptoma prijavljuje se u provinciji Hubei, a raste broj ljudi kojima je urađen test nukleinske kiseline. Taj rezultat pokazuje da virus, koji kruži među stanovnicima, nije visoko zarazan, naveo je zvaničnik iz Kineskog centra za kontrolu i prevenciju bolesti.

Feng Ciđijen, zamenik direktora Kineskog centra za kontrolu i prevenciju bolesti je naveo da većina asimptomatskih slučajeva, koji su potvrđeni tokom masovnog testiranja u provinciji Hubei, ima veoma nisku stopu infekcije.

U provinciji Hubei je sprovedeno 4,3 miliona testova od 8. aprila do nedelje, a potvrđeno su svega 733 asimptomatska slučaja.

Uz rast broja ljudi koji su testirani na koronavirus, broj asimptomatskih slučajeva se i dalje smanjuje, što pokazuje da je sadašnji postojeći virus slablji zahvaljujući uvođenju mere ranog otkrivanja i lečenja bolesnika.